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Fentanyl is also used in the management of chronic pain including cancer pain. Often, transdermal patches are used. The patches work by slowly releasing fentanyl through the skin into the bloodstream over 48 to 72 hours, allowing for long-lasting pain management. Dosage is based on the size of the patch, since, in general, the transdermal absorption rate is constant at a constant skin temperature. Each patch should be changed every 72 hours. Rate of absorption is dependent on a number of factors. Body temperature, skin type, amount of body fat, and placement of the patch can have major effects.

The different delivery systems used by different makers will also affect individual rates of absorption. Under normal circumstances, the patch will reach its full effect within 12 to 24 hours; thus, fentanyl patches are often prescribed with a fast-acting opioid (such as morphine or oxycodone) to handle breakthrough pain. It is unclear if fentanyl gives long-term pain relief to people with neuropathic pain. It is quite cheaper to buy fentanyl online Australia on our website.

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The most dangerous adverse effect of fentanyl is respiratory depression, that is, decreased sensitivity to carbon dioxide leading to reduced rate of breathing, which can cause anoxic brain injury or death. This risk is decreased when the airway is secured with an endotracheal tube (as during anesthesia). This risk is higher in specific groups, like those with obstructive sleep apnea.

Other factors that increase the risk of respiratory depression are:

• High fentanyl doses
• Sleep
• Older age
• Simultaneous use of CNS depressants like benzodiazepines, barbiturates, alcohol, and inhaled anesthetics
• Hyperventilation
• Decreased CO₂ levels in the serum
• Respiratory acidosis
• Decreased fentanyl clearance from the body
• Decreased blood flow to the liver
• Renal insufficiency

Sustained release fentanyl preparations, such as patches, may also produce unexpected delayed respiratory depression. The precise reason for sudden respiratory depression is unclear, but there are several hypotheses:

• Saturation of the body fat compartment in people with rapid and profound body fat loss (people with cancer, cardiac or infection-induced cachexia can lose 80% of their body fat).
• Early carbon dioxide retention causing cutaneous vasodilation (releasing more fentanyl), together with acidosis, which reduces protein binding of fentanyl, releasing yet more fentanyl.
• Reduced sedation, losing a useful early warning sign of opioid toxicity and resulting in levels closer to respiratory-depressant levels.

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There is no safe level of drug use. Use of any drug always carries some risk. It’s important to be careful when taking any type of drug. Still looking for how and where to purchase fentanyl opioids online Australia? You’re lucky to find us.

Fentanyl affects everyone differently, based on:

• size, weight and health
• whether the person is used to taking it
• whether other drugs are taken around the same time
• the amount taken
• the strength of the drug (varies between drug form e.g. patches, lozenges or injection).

Its effects may include:

• euphoria
• relief from pain
• nausea, vomiting
• constipation and/or diarrhea
• reduced appetite
• wind, indigestion, cramps
• drowsiness, confusion
• weakness or fatigue
• dizziness
• headache
• incoherent or slurred speech
• impaired balance
• slow pulse and lowered blood pressure
• rash (inflammation, itch, swelling at patch site).^{1, 4}

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This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Tell your doctor promptly if you develop a fever, since this rise in body temperature may cause overdose (see also Warning section). Avoid activities that might cause your body temperature to rise. (such as doing strenuous work/exercise in hot weather).

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Tell your doctor right away if you have any serious side effects, including: interrupted breathing during sleep (sleep apnea), mental/mood changes (such as agitation, confusion, hallucinations), severe stomach/abdominal pain, difficulty urinating, slow/fast/pounding heartbeat, signs of your adrenal glands not working well (such as loss of appetite, unusual tiredness, weight loss). Get medical help right away if you have any very serious side effects, including: fainting, seizure, slow/shallow breathing, severe drowsiness/difficulty waking up.

This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness.

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The effects of taking fentanyl with other drugs – including over-the-counter or prescribed medications – can be unpredictable and dangerous, and could cause:

Fentanyl + alcohol: adds to adverse effects and may increase the risk of respiratory depression.

Fentanyl + monoamine oxidase inhibitors (MAOI) antidepressants: may result in severe unpredictable reactions. MAOI were the first type of antidepressants developed but generally have been replaced by ones that are safer and have less side effects.

Fentanyl + benzodiazepines: may add to the sedative effects and diminished breathing.¹

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